diff --git a/mitmproxy/addons/script.py b/mitmproxy/addons/script.py
index e90dd8855..b4274f8c3 100644
--- a/mitmproxy/addons/script.py
+++ b/mitmproxy/addons/script.py
@@ -52,11 +52,19 @@ class Script:
 
     def tick(self):
         if time.time() - self.last_load > self.ReloadInterval:
-            mtime = os.stat(self.fullpath).st_mtime
+            try:
+                mtime = os.stat(self.fullpath).st_mtime
+            except FileNotFoundError:
+                scripts = ctx.options.scripts
+                scripts.remove(self.path)
+                ctx.options.update(scripts=scripts)
+                return
+
             if mtime > self.last_mtime:
                 ctx.log.info("Loading script: %s" % self.path)
                 if self.ns:
                     ctx.master.addons.remove(self.ns)
+                    del sys.modules[self.ns.__name__]
                 self.ns = load_script(ctx, self.fullpath)
                 if self.ns:
                     # We're already running, so we have to explicitly register and
diff --git a/test/mitmproxy/addons/test_script.py b/test/mitmproxy/addons/test_script.py
index dd5349cb7..03b1f6208 100644
--- a/test/mitmproxy/addons/test_script.py
+++ b/test/mitmproxy/addons/test_script.py
@@ -1,6 +1,7 @@
 import traceback
 import sys
 import time
+import os
 import pytest
 
 from unittest import mock
@@ -183,6 +184,20 @@ class TestScriptLoader:
                     scripts = ["one", "one"]
                 )
 
+    def test_script_deletion(self):
+        tdir = tutils.test_data.path("mitmproxy/data/addonscripts/")
+        with open(tdir + "/dummy.py", 'w') as f:
+            f.write("\n")
+        with taddons.context() as tctx:
+            sl = script.ScriptLoader()
+            tctx.master.addons.add(sl)
+            tctx.configure(sl, scripts=[tutils.test_data.path("mitmproxy/data/addonscripts/dummy.py")])
+
+            os.remove(tutils.test_data.path("mitmproxy/data/addonscripts/dummy.py"))
+            tctx.invoke(sl, "tick")
+            assert not tctx.options.scripts
+            assert not sl.addons
+
     def test_order(self):
         rec = tutils.test_data.path("mitmproxy/data/addonscripts/recorder")
         sc = script.ScriptLoader()